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Never discontinue prescribed B12 treatment without medical supervision, particularly if you have pernicious anaemia or neurological symptoms of deficiency

You are correct that at the heart of the matter are two key factors: 1

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In the studied context, a review of six clinical trials found a safety profile comparable to placebo, without the IGF-1 effects of full growth hormone

There are a few things that help methylation demand which are worth considering like 5g creatine and 500mg to 1g of TMG